When a promised job for Texan Michael fails to materialise in Wyoming, Mike is mistaken by Wayne to be the hitman he hired to kill his unfaithful wife, Suzanne. Mike takes full advantage of the situation, collects the money and runs. During his getaway, things go wrong, and soon get worse when he runs into the real hitman, Lyle.
艾迪(湯姆·哈迪 Tom Hardy 飾)是一位深受觀(guān)眾喜愛(ài)的新聞?dòng)浾?和女友安妮(米歇·威廉姆斯 Michelle Williams 飾)相戀多年,彼此之間情十分要好。安妮一名律師,接手了命基金會(huì)的案件,女友的郵箱里,艾發(fā)現(xiàn)了基金會(huì)老板雷克(里茲·阿邁 Riz Ahmed 飾)不為人知的秘密。為此,艾迪僅丟了工作,女友離他而去?! ≈?,生命基金會(huì)的朵博士(珍妮·斯蕾 Jenny Slate 飾)找到了艾迪,希望艾迪能幫助她阻止德雷克狂的罪行。在生命金會(huì)的實(shí)驗(yàn)室里,迪發(fā)現(xiàn)了德雷克進(jìn)人體實(shí)驗(yàn)的證據(jù),且在誤打誤撞之中外星生命體毒液附?;氐郊液?,艾迪毒液之間形成了共關(guān)系,他們要應(yīng)對(duì)是德雷克派出的一又一波殺手?